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KMID : 1161520220260060338
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Animal Cells and Systems
2022 Volume.26 No. 6 p.338 ~ p.347
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Elucidating breed-specific variants of native pigs in Korea: insights into pig breeds’ genomic characteristics
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Lee Young-Sup
Son Seung-Woo
Lee Hak-Kyo
Lee Ra-Ham
Shin Dong-Hyun
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Abstract
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Although conserving native pig breeds is important in Korea, research on the genomic aspects to identify breed-specific variations in native pig breeds is uncommon. Single nucleotide polymorphisms (SNPs) can be a powerful source for identifying breed-specific variants. We used whole genome sequencing data, including Jeju Native Pig (JNP), Korean Native Pig (KNP), Korean Wild Boar (KWB), and other western commercial pig breeds to determine native pig breed-specific SNPs. Furthermore, the goal was not only to determine the genomic specificity of native pig breeds but also to identify SNPs that carry breed-specific information (breed-informative SNPs) that can be related to breed characteristics. The representative characteristics of native pigs are their unique meat quality and disease resistance. We surveyed the gene ontology (GO) of native pigs with breed-specific SNPs. Examining the genes associated with GO may contribute to revealing the reasons for the unique characteristics of native pig breeds. The enriched GOs terms were neuron projection development, cell surface receptor signaling pathway, ion homeostasis in JNP, cell adhesion and wound healing in KNP, and DNA repair and reproduction in KWB. We expect that this study of breed-specific SNPs will enable us to gain a deeper understanding of native pigs in Korea.
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KEYWORD
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Breed-specific SNPs, breed-informative, genomiccharacteristics, native pigs, whole genome sequencing
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